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Oxygen Enriched Water- The Science Behind Healthy Cells

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The fact that oxygen is physically attached to the water molecule, is of great importance in oxygen therapy.

The Oral Oxygen (O2) – Therapy (POT)
was developed and applied in a clinical environment by Prof. Dr. med. A. Pakdaman initially in 1970. In 1988 he introduced the
method in Germany and Europe, where it would then be applied during therapy.
The unique method of the oxygen therapy has since been introduced in the area of clinical research in the medical, as well as in the
food supply.

On December 4 th, 1993 Prof. Dr. Pakdaman was awarded by a German Research Foundation in Munich / Germany for the best
research in biological and natural medicine in Germany on his clinical-scientific research regarding Oral resp. Peroral Oxygen-Therapy
(OOT/POT) with the annual “Manfred-Koehnlechner-Price”.
On 10 November 2000 Prof. Dr. Pakdaman was honoured with the Certificate of Innovations for his clinical and scientific work in the
area of oncology and oxygen research, especially the peroral oxygen therapy (POT).

The principal source of oxygen for human consumption is the breathing air.
The air is consisting of a mixture of different gases and contains about 21 % by volume of oxygen, 78 % of nitrogen. Less than 1 % of
this mixture are noble gases such as argon, helium, neon, radon, krypton, and xenon and 0,03 % carbon dioxide.
Oxygen is most widely spread and an indispensable element for life on earth. It participates in all biological and bio-energetic
processes of our body, soul, and mind. As a therapeutic tool oxygen can be used to cure many cellular malfunctions like cellular and
organ detraction.
Lack of oxygen (oxygen insufficiency) can bring serious health problems for human as well as for most creatures. In laboratory in
cultivated cells, lack of oxygen triggers irregular, disturbed DNA syntheses. (14)
Oxygen participates in all burning processes outside and inside the body. During the procedure carbon dioxide, water, waste products,
and energy are liberated. This energy is used for all cell functions.
The human body can survive without solid food for about 2 weeks, without liquids for less than a week, but cannot survive without
oxygen for more than minutes. The oxygen is indispensable for the great majority of life forms on earth.
The atmosphere contains 21 % of oxygen. Oxygen is also solved in water. In a waterfall for example, the oxygen is found in a higher
concentration. Water can be enriched with oxygen leading to a water that contains more oxygen than it did before, what means that it
is of higher quality.
Oxygen as the most frequent element is nature is distributed in the most important natural components.
Oxygen is constituent of the air, of water, and of the earth.
Table 1 lists the content of oxygen in nature as a part of the air, in fixed form in water as well as in oxides, carbonates, and silicates
of the earth crust.
Table 1: Distribution of oxygen in nature
Water 89 %
Earth’s crust (lithosphere) 46 %
Atmosphere 21 (vol.)
Water is covering three quarters of the earth’s surface. It is found as ice in the polar regions. Lakes and rivers, clouds and rain consist
of this fundamental compound. Life happens in “aqueous solution”.
Water is the origin of life
Water is the mother of all liquids
Water is the optimum solution to transport substances in our body
Water is indispensable to use participates to regulate all processes in our body and in nature
Water helps the absorption process of all essential elements in our body
Water raises kidney-function and improves secretion of urine
Water improves the stomach-intestine-passage beside better secretion of waste products and intestine restoration
Water improves stimulation and modulation of immune stations located in intestine area of the immune system
Water improves metabolism
Water improves the decontamination respectively the cleaning process by secretion of waste products and toxic elements of
the body

Water improves the heart -blood-circulation-function and optimises blood circulation
Water operates as a solvent, promotes the transport of food and energy-forming material as well as that of medicine in the
body up to the target organs through smallest capillaries
Water improves the self regulation process by regulation of water-, electrolyte, and- temperature process
Water improves and stabilises the function of CNS. A lack of water in brain or nerve cells can create heavy damage and
function disturbances
All body liquids (blood, urine, expectorate, gall, gastric juice etc.) consist mainly of water and function through water
Water in cellular range is participating with approx. 63 % intracellular and approx.
37 % extra cellular of total body water
Important lack of water in the body is leading to cellular and organic structure and function disturbances with psychical and
mental participation, which finally might lead to death.
Water regulates and stabilises the energy process of the cells, as a function of ion-channels
And mitochondria as well as ADP-ATP synthesis and function of breathing chain
Water functions as an electric dipole and biological, effective, memory-, energy- and information storing and giving remedy

Oxygen and water are the basic components of nature. Their balance creates freshness, vitality, and is the important factor in
improving the quality of life.
Clinical results have shown, that the amount of nitrate in water is reduced, when the water is oxygen enriched. This improves the
quality of water and makes the water healthier for every one, specially children. (9+12)
Oxygen will effect a reaction with hydrogen (H+) in the parietal cells and thereby reduce the formation of stomach-acid (Hcl) 1⁄2 O2 +
2e + 2H+ à H2O (10)
In water gaseous oxygen is physically dissolved. Its concentration is temperature dependent. The quantity of dissolved oxygen (mg/l)
in warm water is smaller than it is in cold water.
The fact that oxygen is physically attached to the water molecule, is of great importance in oxygen therapy. (7)
Following the enrichment of water with oxygen, the oxygen molecules are located between the water molecules, in so called “water
recesses” and are covered by a water membrane. When this water membrane is splitting, the oxygen released.
When the oxygen enriched water gets into contact with mitochondrial tissue (glands, intestine, liver, kidneys, brain, heart, etc.) the
water membranes are ripped open and the oxygen is released to the cells.

Oxygen partial pressure (pO2) is an important parameter, allowing the determination of oxygen content in the blood. It is a very
important factor in determining the relation between the oxygen enriched water and the level of physically solved oxygen in the blood.
Growing older, the amount of pO2 decreases and tissue experiences oxygen deficiency.
It was observed, that the increase of pO2 in blood is considerably after drinking oxygen enriched water.
Table 2: Determination of pO2 in venous blood before and after peroral oxygen treatment with a bottle of 0,33 l
oxygenated water and an oxygen content approx. 45 mg/ l. (the patient lays in a closed room with minimum
O2-content) Institute of Anaesthesiology at the Johannes-Gutenberg-University Mainz / Germany 92/1992)

5 minutes after 10 minutes

15 minutes

20 minutes

30 minutes


Before peroral

drinking of 0,33 l of oxygen enriched water

T 37°C 37°C 37°C 37°C 37°C 37°C
Hb 15 Gr% 15 Gr% 15 Gr% 15 Gr% 15 Gr% 15 Gr%
pO2 19.5 mmHg 33.8 mmHg 31.0 mmHg 30.0 mmHg 29.2 mmHg 28 mmHg

This examination has been performed in 20 patients and probationers. Results were obtained from the blood and by transcutaneous
measurement. The results have been documented.
Oxygen and water are the basic components of nature. Their balance creates freshness, vitality and it is the important factor in
improving the quality of life.
Life began in water and during evolution of earth and organic life creatures spread out over the continents. Interestingly humans still
did not loose the character as a “water creature” during the long fundamental development process.
The condition, that the human have the behaviour of a water creature is kept until birth and even shortly after birth, so that new born
babies are able to swim and survive for a certain period under water; later on this capability gets lost. Indeed the moment of birth is
the moment of metamorphosis or the transition phase from water creature to human bring with pulmonary resp. air (oxygen) breathing.
History of development shows that the human embryo in a early stage of life (intrauterine life) requires for living and development
unconditionally water resp. amnion fluid (water in which embryo is swimming).
Amnion fluid in its vital composition of protein, glucose, creatinine, urea, phospholipids, oestriol, O2, CO2 etc. and a pH-value of 7
functions on one side as protection of the embryo and on the other side as exchange and transport medium on this stage of life.
Indeed it can be called as a kind of “water life”.
Due to this historical background and the scientific possibilities it is possible to support and maintain the lung function in certain cases
like acute pulmonary disease (malfunction) or collapsing lung with high concentrated oxygenated liquid. In this process the oxygen
content will be installed in the bronchia. The oxygen in the water will be consumed by the alveolus and by that improving the
optimising of the breathing function resp. the biological oxidation. This process can be named as a sign of nature- and origin
relationship or in other words as return to origin, which can be certainly of decisive therapeutical significance in future medicine.
Primitive, microbial organism as well as single cell components requires water resp. intra- and extracellular fluids for their function.
If the water molecule (H2O) can be seen as a connection of 2 gases, a gaseous condition is expected. A precise view of the molecular

structure shows a bridge construction between the single water molecules, which finally lead to big molecular units. This water-
structure have physical possibilities of forming connections with other material and elements, among gases like oxygen.

It has to be mentioned, that beside the daily consumed water through specific biological body processes like oxidation a certain
quantity of water will be produced, which is named as oxidation water. The breathing chain as most important energy producing
process for instance delivers under normal condition approx. 300-400 g water/ day.
Furthermore body fluids as well as intra- and extracellular fluids as life-important liquids of the body consisting for the most part of
water. This liquid body condition participates on various biological- and bioenergetical body functions, like functions of ion channels and
ion transport, transport of food and hormones, water-, electrolyte- and heat household transfer, energy forming of the cell,
information- and energy transfer and exchange.
Water stabilises the morphological cell structure as well as the functionary preservation of life on atomic, molecular and cellular level
and finally:
Water is an universal, existential, mystical medium. It has a memory function, it stores and gives information and energy. It follows
the law of polarity, it is a good natured, profitable, constructive and life giving component of nature as well as mean, damaging,
destructive and life taking component of nature with a profile of energy and matter as well as a high potential strength of nature as an
important parameter for life forming and life keeping.

Organic bloodcirculation as one of the existential lifeprocesses basically functions through the capacity of the heart -vascularsystem
and improves the absorption of nutrition and oxygen provision of the tissue.
Pathological alterations in any range of this system might lead to disturbances in bloodcirculation with subsequent complications.
Table 3: Blood circulation in different organs and oxygen uptake in rest, 70 kg body weight
Organ / area Blood circulation (%) Oxygen uptake (%)
Brain 13 20
Heart 4 11
Abdominal area 24 25
Kidneys 19 7
Skeleton muscles 21 30
Skin 9 2
Other organs 10 5
The administration of oxygen enriched water to organs as there are brain, heart, lung, abdominal area as well as to eyes and the
immune system resulted in a positive therapy effect and improved regulation mechanisms.

By a deficient oxygen uptake or oxygen efficiency, severe and destructive processes can be caused in humans and other organisms.
An optimal oxygen uptake is absolutely necessary to maintain the bio reactions of the body and for a healthy life.
Oxygen saturation of the blood and pO2 play a decisive role.
Fig.2: Average pO2 of blood depending on age

A reduction of O2 content in the blood is observed with increasing age.
Numerous liquids with different chemical properties and concentrations can be enriched, empowered, and dynamised by enrichment
with gases, esp. with oxygen and can be used with positive effects in medicine, environment, and industry.
In a study different liquids have been enriched with oxygen by a new special method (Pakdaman, A.) (6)
Table 4: Oxygen content of different liquids before and after enrichment with oxygen
Liquid Temperature °C O2-content in mg/ l
before enrichment

O2-content in mg/ l
after enrichment
Drinking Water 20 7,0 80,0
Distilled Water 20 11,2 42,5
Mineral Water 20 1,5 42,0
Sodium chloride solution,

16 8,0 45,0

Sodium chloride solution,

16 8,2 45,0

Haemaccell 35 blood

20 8,1 39,0
Milk 22 1,7 40,0
Orange juice 21 5,2 40,0
Beer 21,7 0,2 30,8
Isostar 20,7 0,5 40,1
Cola 21 0,4 24,1
The development in the last years made it possible to achieve an enrichment of drinking water with oxygen to more than 80 mg/ l.
Recently the interest in nutritional science has rapidly grown and new means were developed to combine oxygenated water and to
study their effect on the human body. The following is an attempt to address the oxygen enriched water issue.
At present, the earth has a population of almost 6 billion people with a consumption of about 12 billion litres of drinking water each
day. According to recently published statistical data, about 36% of earth population suffer from oxygen deficiencies. This situation
creates a big responsibility for every government to overcome these deficiencies and to provide healthy drinking water and oxygen for
human consumption.
To support the human body functions and its energy requirement the food should contain the so called “essential elements”. These
essential elements are partially entering the human body in liquid form.

Apart from the essential elements, the oxygen and water play an indispensable role for living things.
The Oral Oxygen Therapy (O.O.T.), as an innovation in medicine and biology, with promising prospects for treating different medical
conditions, has been developed for the first time in 1970 by Prof. Dr. A. Pakdaman, M.D. This therapy was introduced in Germany in
late 1988.
The oxygen enriched water has been applied in the nutritional, clinical and research medicine, to treat cellular hypoxia. As therapy, the
oxygen enriched water was prescribed for people suffering from different diseases, such as migraine, heart arrhythmia,
ophtalmological problems and cancer. Also, the therapy was used to improve blood pressure and to stimulate the immune system.
In 1993, the “Manfred Köhnlechner Stiftung”, a German Research Foundation, has given its annual reward for the best research in
biological and natural medicine in Germany, to Prof. Dr. Pakdaman M.D., for its Oral Oxygen Therapy work.
Oral Oxygen Therapy (OOT) can be applied by itself or in combination of other means under physician supervision. According to
research conducted by several scientists, the combined OOT therapy has given the following effects:
· Stimulates and regulates the immune system (Leucocytes, Monocytes, Granulocytes, natural killer cells)
· Increases number of blood cells (erythrocytes, Hct, Hb, Platelets)
· Improves cellular hypoxia and oxygen utilisation disorder
· Converts anaerobic metabolism in cancer cells into aerobic one
· Has antibacterial and antiviral effects specially on anaerobic bacteria
· Addresses Gastrointestinal problems such as: heartburn, gastritis, gastric ulcer, duodenal ulcer, etc.
· Decreases the formation and secretion of acid gastric
· Improves micro circulation specially in the gastric and intestinal mucosa
· Regulates the function of H+ / K+ – AT Pase enzyme (proton pump).+
· Regulates stomach motility
· Activates and regulates the function of Lieberkuhn’s and Brunner’s glands
· Has cytotoxic effect on heliobacter pylori
· Effects on hypoxia such as asthma, silicosis, T.B., cystic fibrosis, chain smoking
· Prophylaxis and therapy of migraine due to reduction or elimination of cerebral hypoxia
· Increases the oxygen supply for the brain cells in the case of arteriosclerosis and brain tumor (11)
· Controls Angina pectoris conditions because of improvement of myocardial hypoxia, prevention of massive necrosis of heart
tissues and heart insufficiency
· Acceleration of detoxification process of body because of activation of cytochrome P-450 in the liver
· Hypoventilation due to functional weakness of respiratory tract such as thorax injury, obstructive pulmonary disease or
neuromuscular disorder such as poliomyelitis, myopathies and mechanical load to the respiratory systems such as massive
obesity, kyphosis, kyphoscoliosos
· Improves granulation and regeneration of the tissue (wound haling)
· Improves quality of life
· Delays ageing process
This application of OOT is specially in those cases useful, because oxygen will be transported with this method directly into blood
circulation by gastrointestinal tract and portal vein.
This method is characterised moreover by the following criteria:

The water enriched with oxygen is consisting substantially of 2 existential components of nature, namely oxygen and
The molecular connection in this combination between oxygen and water is based on ionic binding, i.e. it is physically
dissolved oxygen (7)

The absorption organ for this method is not the lung, but the mouth tissue and the gastrointestinal tract
Approx. 5 minutes after oral treatment with oxygen enriched water an increased pO2-value in the blood is observed
This method can be carried out as additional therapy besides of conventional and other therapy-methods
There has been no side effects detected up to now
This method offers a broad spectrum of effects in the range of medicine, biology, nutrition, environment, and industry
Oxygen consumption is a signal of life.
All the biological and bio-energetic processes that take place in a cell are conditioned by the oxygen presence. Without oxygen, i.e. in
hypoxic condition, the cell’s functions are disturbed and its structure is deteriorated.
The function of immune cells, like phagocytes, is among others depending on oxygen. Phagocytosis, the activity of the phagocytes,
as well as the production and consumption of energy in the cell are directly dependent on the oxygen partial pressure.
When oxygen therapy is applied, an improvement of the body defence system is observed, due to the stimulation and stabilisation of
the immune system.
Some factors such as: chemotherapy, radiation, post operative syndrome and stress can trigger hypoxia-lack of the oxygen in the cell.
This condition will result in energy deficiency in the cell and a disturbed immune system and therefore must be addressed by an
adequate therapy.
As a result of the oxygen enrichment process, the energy lever of a fluid is considerably increased, which in terms will allow a more
effective source of energy when ingested.
Absorption of oxygenated water begins in mouth tissue and along the gastrointestinal tract. By diffusion and osmosis, the oxygen
utilising the isotope O2

15, have shown the relationship between the amount of blood received by brain and how effective the oxygen

was utilised. This is the result of the active oxygen transport. (8)
As a result of the oxygen enrichment process, the energy level of a fluid is considerably increased, which in terms will allow a more
effective source of energy when ingested.
About 5 minutes after drinking of oxygen enriched water an increase of the pO2 value is observed in venous blood. In contrast to
oxygen supply via a mask the effect of oxygen applied as an aqueous solution lasts for several hours. Even after 3 to 4 hours still an
elevated oxygen content in the blood is observed.
Resorption of oxygen occurs in following way.
Oxygen enriched water à capillaries of the mucous membranes of mouth and gastrointestinal tract à portal vein à liver circulation à
body circulation à increase of pO2 in the blood à reaching of organ of destination via the haematogenous way
The effect of Oral Oxygen Therapy (OOT) in the therapy of head and neck carcinomas has been measured by pO2-histography. (1)
The measurement of oxygen partial pressure in tissues has been done by Kimo pO2-histography equipment. With this method the
oxygen partial pressure has been measured with a pO2 micro sond.
This way, it was possible to measure and register the increase in oxygen concentration in cancer cells after Oral Oxygen Therapy
(OOT) according to Pakdaman.
Eble, M.J. et al (2) reported the results obtained in 20 patients, who had been treated previously by radiotherapy against lymphogene
metastasised mount bottom and pharynx carcinomas. pO2-measurement was carried out before and 5 minutes after treatment with
300 ml oxygenated water (60 mg O2/ l). A pO2-increase in the blood could be detected 5 minutes postprandial. After further
examinations an increase tumour oxygenation was detected.
It could be demonstrated, that the increase in oxygen concentration in cancer cells made the cells sensitive against chemical therapy
and radiation, therefore helping the destruction of cancer cells. (4)
In 32 patients with previously treated with surgery, radiation, and/ or chemotherapy were treated with pharmacological doses of
sodium selenite as the whole blood selenium level were subnormal in 70 % of patients. In 76 % of patients a definite and in 24 % a
slight improvement of the general condition and a decrease of symptoms such as nausea, emesis, headache, vertigo, unsteady gait,
speech disorders and Jacksonian seizures were observed. Additional beneficial effects were observed in patients receiving the oxygen

therapy. (A. Pakdaman 1998) (11)
Several studies indicating that hypoxia of tumortissue at various malign diseases will have a negative effect on the whole lifecourse of
the patient including free of recidivism.
Furthermore tumoroxygenation and revision of anaemia could slow down and even retard tumoragression.
In a study with 182 female patients with mamcarzinon, which has been trated with zytostatica, showed a significant better free of
recedivism survival of such woman, which Hb-value was higher than 10 g/ dl, comparing with female patient with Hb-values under this
value. (Fortbildung Tumortherapie, Universität Heidelberg 1/2000) (3)
Therefore, OOT can play a very important role in any conventional or biological therapy destined to increase oxygen concentration in
cancer cells.
Headache is a frequent human pain disease. In Germany there are approx. 500 different pharmaceuticals against headache on the
medical market. Americans yearly use 15 billion headache pills. For the generation of headaches, including migraine attacks, micro
circulation disorder and cerebral hypoxia play decisive roles.
For a documentary study 12 patients with headache, consisting of 8 woman between 21 and 45 years and 4 men between 32 and 46
years have been examined and treated for approx. 6 weeks by Oral-Oxygen-Therapy (OOT) according to Pakdamen. Patients suffered

from headache, migraine-attacks, tension-headache, hypotonia, dysmenorrhoe, orthostasia etc. The daily dose for the Oral-Oxygen-
Therapy was 0,33 l water enriched with oxygen 2-3 times a day.

Seven of eight female patients had migraine headache and one had tension headache. Two men of four had migraine and one had
tension headache. The fourth had a gliom left temporal.
Table 5: Results of therapy after Oral-Oxygen-Therapy (OOT) according to Pakdaman of 12 headache patients
Result of Therapy

improved slightly improved

Diagnosis No. of

female male

female male female male

Migraine 9 7 2 6 2 1


2 1 1 1 1

Gliom left

1 1 1
Sum 12 8 4 6 3 2 1

Fig. 3: Results of therapy after Oral-Oxygen-Therapy (OOT) at 12 headache-patients (n=12), suffering from:

migraine 9
tension-headache 2
gliom left temporal 1

In the range of a documentation 6 patients with eye diseases, 3 female patients in the range of 56 and 81 years and 3 male patients
in the range of 53 and 76 years has been examined and treated 4 weeks ambulant with Oral O2-Therapy (OOT) according to
Pakdaman and afterwards their relevant datas has been controlled. As antioxidants and radical captur the patient was treated with
vitamin A, E, C and Zinc. Under consideration of the diagnosis basically the relevant diseases was intra-ocular pressure, vissum,
faceara and front eye section as well as cornea-alterations.
53-year old patient with sicca-sydrom and gland-papillae has been treated 4 weeks with Oral Oxygen Therapy. After treatment a
subjective and objective improvement was documentated.
Computer-perimetry before and after OOT:
Fig. 4: By computer-perimetry evidenced defect before OOT (53-year old Patient)

Fig. 5: By computer-perimetry evidenced distincive decreasement of scotom in faceaera after OOT (similar patient)

Table 6: Status of the patient before and after OOT
Diagnosis Condition before OOT Condition after OOT

Increased intra-ocular pressure
T right 20 mm Hg
T left 19 mm Hg

Decreased intra ocular pressure
T right 13 mm Hg
T left 13 mm Hg
Improvement of Faceaera and visus
More vital papillae- Stability of psychis

In the course of a clinical study 6 patients with heart failure (cardiac arrhythmia), 2 female and 4 male patients in the age between 41
and 70 years have been cardiologically examined and treated with Oral Oxygen Therapy (OOT). (13)
After OOT significant improvements could be evidenced and documented.
Table 7: Results of longterm ECG according to Lown classification and different values before and after Oral Oxygen Therapy

(OOT) at patients with cardiac arrhythmia.
Pat. Age Diagnosis Lown-Changes
before OOT after OOT
1 42 Cardiac arrhythmia, VES, Hypotonia Lown IV a Lown II
2 70 Cardiac arrhythmia, massive SV-Tachycardie, Hypotonia,

Vertigo, Osteoporosis of spine

Lown III b

Lown I

3 52 Cardiac arrhythmia, VES, Hypotonia, heavy headache,


Single VES No VES

4 60 Cardiac arrhythmia, massive VES, status after. ACVB at

3 vascular, CHD, Hypotonia

Lown IV Lown III a

5 41 Cardiac arrhythmia, CHD at 3 vascular Hypotonia, Angina


Normal Normal

6 64 Cardiac arrhythmia, VES, CHD, Hypotonia, LHH, status

after ACVB and hip joint operation

Lown IV a Lown III a

Table 8: Results of exercise ECG and different values before and after Oral Oxygen Therapy (OOT) at patients with cardiac
Pat. Age Diagnosis Exercise ECG
before OOT after OOT
1 42 Cardiac arrhythmia, VES, Hypotonia 75 W 100 W
2 70 Cardiac arrhythmia, massive SV-Tachycardie, Hypotonia,

Vertigo, Osteoporosis of spine

50 W 75 W

3 52 Cardiac arrhythmia, VES, Hypotonia, heavy headache,


100 W 125 W

4 60 Cardiac arrhythmia, massive VES, status after. ACVB at

3 vascular, CHD, Hypotonia

75 W 100 W

5 41 Cardiac arrhythmia, CHD at 3 vascular Hypotonia, Angina


100 W 150 W

6 64 Cardiac arrhythmia, VES, Hypotonia, LHH, status after

ACVB and hip joint operation

75 W 100 W

Fig. 6: Improvement of heartcapacity after treatment with oxygenated water

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